Pharmaceutical Chemists together with other scientists at the US-based international pharmaceutical franchise, Pfizer, synthesized Sildenafil Citrate – a PDE5-inhibitor – some twenty-two years ago and studied its characteristics, which made it suitable for Erectile Dysfunction therapy. They wasted no time in registering a patent for this substance, which the intended to make the active pharmaceutical ingredient in the first oral ED medication. The company introduced that medication to the market two years later under the Brand name Viagra following approval by US Food and Drug Administration as a prescription-only medication.
Viagra was distributed under a dual-patent, one of which reserved the right to use the medication for treatment of Erectile Dysfunction patients. Pfizer also synthesized a liquid formulation of Sildenafil known as Revatio, which was to be used to treat Pulmonary Arterial Hypertension (PAH). The patent is set to expire in the United States sometime in 2018 and European Viagra patent already expired in 2013. This development has led many of the world’s finest generics manufacturers (particularly those based in India) to develop their own generic brands of Sildenafil. As such, EU residents are already able to purchase these generics over the counter and without a prescription, preferably on the Internet.
Original Brand name Viagra by Pfizer is available in the market in three dosage strengths of one hundred milligrams, fifty milligrams, and twenty-five milligrams. Viagra is synthesized in the form of blue, diamond-shaped tablets in film coating. Every tablet of each of the three dosage strengths contains an equivalent amount of Sildenafil Citrate as the active pharmaceutical ingredient. The maximum recommended dose of Sildenafil approved by the Food and Drug Administration for Impotence and Erectile Dysfunction is one hundred milligrams. The same applies to generic Sildenafil 20mg and others.
Sildenafil 20 mg Сost
Producers of generic Sildenafil drugs usually synthesize these medications in the three traditional dosage strengths in which Pfizer markets Viagra. Aside from that, however, many producers have decided to include intermediate dosages. So, you are bound to come across 20 milligrams Sildenafil drugs like Teva 5517 by Israel-based multinational pharmaceutical company: Teva Pharmaceuticals Inc. or 20mg Sildenafil pills by US-based Marley Drug, Sildehexal seventy-five milligrams Sildenafil by Germany-based Hexal AG, and drugs including dapoxetine for combating premature ejaculation like Super P Force one hundred and sixty milligrams Sildenafil/Dapoxetine preparation by Sunrise Remedies Pvt Ltd based in India.
Attempting to find generic Sildenafil 20 milligrams or any generic Sildenafil preparation in outlets of leading retail franchises like CVS, Walmart, GNC, and Walgreens will ultimately be unfulfilling as they typically don’t stock generics in their pharmacies. For that, customers will do well to search for a desired generic in the generic pharmaceuticals vendor market using the Internet. One of the advantages this market affords, which immediately becomes apparent is that buyers are not mandated to provide a prior prescription for orders to be duly processed. The drugs on these websites are inexpensive considering the cost of Viagra. 30 tablets of that drug cost 24.83 dollars per pill on the average.
Viagra substitutes, irrespective of the particular dosage strength or medicinal form (coated or uncoated tablets, Soft tablets, sublingual tablets, or capsules), are effective for treating Erectile Dysfunction and impotence because they contain Sildenafil Citrate as the chief pharmacologically active ingredient. Sildenafil Citrate inhibits the enzyme known as phosphodiesterase type-5 and its biological half-life has been calculated to be about 4 to 6 hours, meaning that it could remain effective for as long as twelve hours after. PDE 5 is abundant in the walls lining the penis’ corpus cavernosum as well as the arterial walls in the region. The enzyme is involved in degrading a small molecule called cyclic guanosine monophosphate and Sildenafil is tasked with stopping this when it gets transported to the region. CGMP presence in the region increases, which helps it to dilate blood vessels after the smooth muscles relax.
Prospective customers will do well to bear in mind that the access granted by generic pharmaceutical vendors does not mean that they no longer have to see their doctors about any problems they have observed with developing erections and overall sexual performance. It is best a qualified doctor performs a physical examination to determine whether or not you have serious problems. If the diagnosis is positive, you will benefit from the additional information a doctor will give you before writing a prescription for generic Sildenafil 20 milligrams tablets or something similarly effective. You get to learn about contraindications, hypersensitivity reactions, and drug interactions. This will go a long way towards helping you avoid rarely seen but severe side effects of Sildenafil use.
Original Brand name Viagra by Pfizer is available in the market in three dosage strengths of one hundred milligrams, fifty milligrams, and twenty-five milligrams. Viagra is synthesized in the form of blue, diamond-shaped tablets in film coating. Customers can find generic 20 milligrams Sildenafil drugs like Teva 5517 by Israel-based multinational pharmaceutical company: Teva Pharmaceuticals Inc., as well as 20 milligrams a Sildenafil formulation produced by Marley Drug Inc., which is based in North Carolina in the United States. The motivation of this dosage, which is less than the lowest FDA-approved dose, is to aid patients having difficulty with toleration.
Other intermediate dosages are available on the market like, for instance, Sildehexal seventy-five milligrams Sildenafil by Germany-based Hexal AG, and drugs including dapoxetine for combating premature ejaculation like Super P Force one hundred and sixty milligrams Sildenafil/Dapoxetine preparation by Sunrise Remedies Pvt Ltd based in India. Generic pharmaceutical vendors operate websites where prospective buyers can place an order to purchase any generic Sildenafil medication without having to submit a prior prescription. Browse our TOP list of Internet pharmacy drugstores to find a trustworthy vendor.