Tadalafil – What is This Drug and Who Can Use It?
Tadalafil rings a bell when it comes to impotence treatment—it is actually one that buyers call “Cialis”, the trade name for a powerful erectile dysfunction drug with a staggering benefit of 36 hours in the patients.
The brainchild of the massive historical US company, Eli Lilly, Tadalafil or Cialis has now become one of the most sought-after medicines when it comes to mitigating erectile dysfunction symptoms in patients. Cialis, though, has become exceedingly expensive due to its price monopoly in the market, hence giving birth to the need for cheaper drug alternatives to the product.
Tadalafil, the active ingredient found in the drug Cialis, is classified as a phosphodiesterase type-5 inhibitor drug. It belongs to the same family as Sildenafil Citrate, the active ingredient of the product Viagra from Pfizer. Tadalafil, though, came much later than Viagra’s Sildenafil Citrate—the drug was approved by the US FDA in 2003, whilst Sildenafil Citrate was distributed worldwide in 1998.
What medical conditions can Tadalafil treat?
The drug Tadalafil’s use is primarily for impotence treatment or clinical erectile dysfunction. However, this particular drug is also used for other medical applications, such as the treatment of benign prostatic hyperplasia (BPH) symptoms in males. Cialis, the brand name treatment for impotence, is the same drug marketed by Eli Lilly for BPH management in male patients.
In some research studies, Tadalafil is able to accomplish the following in patients suffering from BPH:
- lessen the size of the enlarged prostate
- assist the patients in augmenting their urine output
- relieve urinary retention
Apart from erectile function improvement and BPH symptoms relief, Tadalafil’s use is also applied to patients suffering from pulmonary arterial hypertension (PAH). Patients with primary PAH are given Tadalafil to improve their exercise capacity and relieve their arterial blood pressure.
Since all three medical conditions are responsive to Tadalafil’s mechanism of action, Tadalafil is presently one of the known clinical treatments for these medicinal concerns. All three conditions BPH, ED, and PAH are relieved by Tadalafil’s inhibition of the phosphodiesterase enzyme and Tadalafil’s direction of an augmented blood supply to key tissues of the body.
Whilst the same Tadalafil pertinent to impotence and BPH treatment is also relevant to PAH treatment, there is a separate brand for PAH marketed by companies like Eli Lilly. Instead of recommending Cialis to patients suffering from preliminary PAH, patients are prescribed Adcirca, another Tadalafil containing medicine with a different trade name. Interesting enough, according to Adcirca and Cialis monographs, these two drugs aren’t interchangeable despite their identical active contents.
Tadalafil vs Sildenafil: Similarities and Differences
One of the most significant inquiries regarding impotence treatments is the one about the difference between Tadalafil and Sildenafil. Sildenafil Citrate (Viagra) and Tadalafil (Cialis) are two of the illustrious names in erectile dysfunction treatment. These are not only famous due to their manufacturers (Pfizer for Viagra and Eli Lilly for Cialis), they are also renowned for their invaluable benefits in patients suffering from erectile dysfunction. Tadalafil and Sildenafil Citrate are nearly identical drugs, but they have qualities that set them apart as well.
- Use – These two drugs are significant for erectile dysfunction treatment and pulmonary arterial hypertension
- Drug classification – Both Tadalafil and Sildenafil are called PDE5 inhibitor drugs
- Common side effects – Headaches, dyspepsia, and nasal congestion
- Intake – About an hour before sexual activity
- Duration – Sildenafil Citrate lasts an average of 4 hours while Tadalafil lasts about 36 hours in the body
- Available doses for ED – Sildenafil: 25, 50, and 100mg tablets, on demand; Tadalafil: 10 and 20mg tablets on-demand, 2.5 and 5mg daily dose
- Onset – Sildenafil Citrate: 30-60 minutes after ingestion; Tadalafil: 1-2 hours after ingestion
- Other uses – Tadalafil, unlike Sildenafil Citrate, is also used for BPH symptoms
- Significant side effects – Sildenafil Citrate: bluish-tinged vision or blurred vision; Tadalafil: backache or malaise
The most significant amongst the differences identified between Tadalafil and Sildenafil Citrate is the duration in the body. Patients using Tadafil can enjoy the benefits of the drug for up to 36 hours (average 12-24 hours), as opposed to Sildenafil’s mere 4-hour effect. Tadalafil’s 36-hour effect caused the drug its “weekend pill” name.
Significantly, Tadalafil also has a “daily” dose, unlike Sildenafil’s only on-demand use. This daily dose allows males to simulate a normal erectile function—males on the Tadalafil dose do not need to time their sexual activities, allowing them no time concerns when it comes to their sexual function.
Despite the differences, both Sildenafil Citrate and Tadalafil still have their respective patrons—some males prefer Tadalafil’s sustained effect, whilst others prefer Viagra’s brief duration and its faster onset.
Tadalafil (Cialis and its generic counterparts) can be taken in two ways for erectile dysfunction. Males can be recommended the on-demand dose of 10 mg to 20 mg when needed. This as-needed Tadalafil dose is taken at least an hour before the intended sexual activity; however, since the drug can last a staggering 36 hours in the body, patients can actually take the product hours prior to the planned sexual activity.
Daily Tadalafil dose, though, is taken on a daily basis (hence the name). Patients prescribed with daily Tadalafil are supposed to take in the drug at the same time every day and not only when there is a scheduled sexual activity. Both doses are effective in patients, although some males do not respond immediately to Tadalafil daily dose. Since Tadalafil’s effect somewhat aggregates over time, patients using the daily dose, are able to experience a better effect from the drug with continued use.
Tadalafil Side Effects Long Term
Long-term side effects from Tadalafil are studied by researchers to determine if the drug is beneficial to the male patients with continued, almost indefinite use. One study published in the European Urology journal in 2004 (from Montorsi et al), studied the long-term effect of Tadalafil use in 1173 men suffering from erectile dysfunction.
Of all the participants, 493 (42.0%) males completed 24 months of as-needed to once daily Tadalafil use, while 234 (19.9%) men completed 18 months of Tadalafil treatment. Overall, Tadalafil was safe and tolerated by the patients, although several side effects such as headache, dyspepsia, nasopharyngitis, and back pain affected 8.2 to 15.8% of the patient population. As for adverse side effects, 8.6% of the patients encountered more severe adverse reactions to Tadalafil treatment. Individual rate for side effects in patients determined by the researchers is less than 1%. Patients discontinuing treatment due to adverse events, though, were only 6.3% of the population. Despite a small fraction of the patient population discontinuing the drug due to adverse events, there were no established patterns for mild and adverse side effects determined in the patients who participated in the study.
All in all, the authors of this study concluded that Tadalafil, when taken as needed to once a day (2.5 to 20 mg) in 18 to 24 months is safe and well-tolerated by patients.
How to Buy Tadalafil Tablets Online
Tadalafil is readily accessible local drugstores, as long as patients are capable of providing the appropriate prescriptions for the drug. However, since brand Tadalafil prices have risen exceedingly in the past years, the need for cheaper Tadalafil options remain.
As you can see in the image above, consumers are currently dealing with a local pharmacy price of $55.25 PER pill for Cialis 20 mg from Eli Lilly. Albeit some may argue that the price tag for Cialis Tadalafil is reasonable especially that the drug can last males more than a day, to spend this amount long-term is unreasonable.
Online pharmacies are the fall-backs when it comes to expensive Tadalafil. There are some online drugstores selling generic Tadalafil counterparts for Cialis, enabling buyers to maximize their savings. Since generic and brand Tadalafil are identical and both contain the same active ingredient, males using the generic drug counterparts are also able to experience the same good effect from Tadalafil.
Whilst Cialis and generic Cialis have the same content, they differ mainly in manufacturer and price. As you can see, generic Cialis pills range only from $1.31 to $3.54 per pill at one online drugstore—a far cry from the $55.25 Cialis 20mg pill price at common local drugstores. However, buyers should be aware of scam drugstores and use only reliable online pharmacies—such as the ones included on our list of Top Online Vendors for the present year.
Tadalafil is one exemplary drug for impotence treatment. It is known by its trade name Cialis, coined by Eli Lilly, and is also famous for its staggering 26-hour effect in the body. This product is widely used worldwide and can be bought at any local drugstore whenever a legal prescription is presented. However, Tadalafil’s brand name version puts on financial pressure on the males purchasing the drug, hence making way for the purchase of generic alternatives for the product. There are benign online pharmacies where you can safely purchase affordable Tadalafil (like the stores encompassed on our list of Top Vendors), though—if you want to spend less on Tadalafil treatment but still relish the same benefits of the drug.